ZIK1

Across TCGA patient cohorts, ZIK1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIK1-associated genes across cancer lineages are MEK1, FoxM1, and Notch1. Each is linked with ZIK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZIK1-to-partner and partner-to-ZIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZIK1-low versus ZIK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIK1→partner) and Y-score (partner→ZIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.403	+2.807	.004	.003	3	3
UCEC	FoxM1 →	+0.211	+2.179	.033	.034	3	2
UCEC	Notch1 →	+0.215	+3.713	<.001	<.001	3	2
UCEC	FOXO3a →	+0.079	+1.335	.041	.046	3	1
UCEC	Ku80 →	+0.293	+2.100	.001	.003	3	1
UCEC	p62 Lck ligand →	+0.398	+2.424	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by ZIK1 expression — UCEC

Explore this box plot interactively →