ZIK1

Across TCGA cell cohorts, ZIK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,158 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZIK1-associated GO terms across cancer lineages are Spliceosomal complex assembly, Regulation of mitotic metaphase/anaphase transition, and Negative regulation of mitotic cell cycle phase transition. Each is linked with ZIK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZIK1-to-partner and partner-to-ZIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal complex assembly grouped by ZIK1-low versus ZIK1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIK1→partner) and Y-score (partner→ZIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Spliceosomal complex assembly →	+0.094	+1.767	<.001	.002	3	12
BREAST	Regulation of mitotic metaphase/anaphase transition →	+0.113	+1.138	<.001	.008	3	12
SKIN	Negative regulation of mitotic cell cycle phase transition →	+0.063	+1.075	<.001	.003	3	11
BREAST	Regulation of metaphase/anaphase transition of cell cycle →	+0.103	+1.178	<.001	.007	3	11
BREAST	Regulation of cell cycle G1/S phase transition →	+0.065	+1.435	<.001	<.001	3	10
BREAST	Protein polyubiquitination →	+0.034	+1.376	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,158 associations by consensus.

Spliceosomal complex assembly by ZIK1 expression — LUNG_SCLC

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