ZIC5

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZIC5 protein abundance is significantly associated with the RNA expression of many other genes, with 1,640 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ZIC5-associated genes across cancer lineages are ANKRD31, TMEM63C, and EIF4A1P8. Each is linked with ZIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC5-to-partner and partner-to-ZIC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZIC5 versus ANKRD31 in HNSC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC5→partner) and Y-score (partner→ZIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCANKRD31 →+0.499+0.590.002.00432
LUADTMEM63C →+1.084+0.524.007.00132
LUADEIF4A1P8 →-0.472-0.582<.001<.00132
LUADBRAFP1 →+0.509+0.387.005.00732
OVUSP51 →+1.027+1.167.001<.00132
OVDYRK3-AS1 →+0.555+1.192.004<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,640 associations by consensus.

ZIC5 vs ANKRD31 — HNSC

Per-sample scatter of ZIC5 vs ANKRD31 in HNSC (Pearson r = 0.51).

Explore this scatter interactively →

Exploration