ZIC5

Across TCGA patient cohorts, ZIC5 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC5-associated genes across cancer lineages are p62 Lck ligand, TFRC, and 4E-BP1. Each is linked with ZIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC5-to-partner and partner-to-ZIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZIC5-low versus ZIC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC5→partner) and Y-score (partner→ZIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.461	+2.999	<.001	<.001	3	2
UCEC	TFRC →	+0.527	+3.459	.004	.005	3	2
UCEC	4E-BP1 →	+0.227	+3.489	.017	.002	3	2
UCEC	14-3-3_beta →	-0.082	-1.973	.020	.029	3	1
UCEC	eEF2 →	+0.382	+2.459	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.349	-3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

p62 Lck ligand by ZIC5 expression — UCEC

Explore this box plot interactively →