ZHX1

Across TCGA pan-cancer cohorts, ZHX1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZHX1 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZHX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZHX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, UCEC, and LUSC are the cancer types where ZHX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
UCEC	DFS	Median	All	1.000	0.596	<.001	36	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
TGCT	DFS	Median	All	0.099	0.801	.011	6	view →
ESCA	DFS	Median	III,IV	0.103	0.442	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZHX1–KIRC (OS)

Open the KIRC breakdown →