ZHX1

Across TCGA pan-cancer cohorts, ZHX1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZHX1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZHX1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZHX1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, LIHC, and KIRP are the cancer types where ZHX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZHX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.866	<.001	10	view →
LIHC	Male	III,IV	+1.248	<.001	8	view →
KIRP	Male	All	−0.856	<.001	7	view →
UCEC	All	All	−0.981	<.001	6	view →
KIRC	Male	II,III,IV	−0.540	<.001	6	view →
COAD	All	All	−0.487	.001	4	view →
BLCA	Female	All	−0.787	.002	3	view →
LUAD	All	IV	+0.265	.039	2	view →
BRCA	Female	All	−0.171	.033	2	view →
HNSC	Female	III,IV	+0.676	.036	1	view →
READ	All	II,III,IV	−0.492	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZHX1–THCA

Open the THCA breakdown →