ZHX1

Across TCGA pan-cancer cohorts, ZHX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZHX1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZHX1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZHX1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where ZHX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.770	0.953	.001	26	view →
LUAD	OS	Tertile	II,III,IV	0.851	0.515	.012	17	view →
CCRCC	DFS	Median	II,III,IV	0.542	0.882	.008	17	view →
LSCC	OS	Tertile	All	0.892	0.636	.005	12	view →
PDAC	DFS	Tertile	II,III,IV	0.615	0.309	.021	6	view →
GBM	DFS	Median	All	0.262	0.475	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZHX1–HNSC (OS)

Open the HNSC breakdown →