ZHX1

Across TCGA cell cohorts, ZHX1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZHX1-associated genes across cancer lineages are CLUAP1, SH3GL2, and PCCB. Each is linked with ZHX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZHX1-to-partner and partner-to-ZHX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLUAP1 grouped by ZHX1-low versus ZHX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZHX1→partner) and Y-score (partner→ZHX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLUAP1 →	+0.678	+3.215	.004	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.547	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PCCB →	+0.667	+3.125	.001	.008	3	1
LARGE_INTESTINE	HRK →	+0.623	+3.241	<.001	.007	3	1
LARGE_INTESTINE	EOMES →	+0.446	+3.302	.001	.008	3	1
LARGE_INTESTINE	ACER1 →	+0.069	+2.823	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CLUAP1 by ZHX1 expression — LARGE_INTESTINE

Explore this box plot interactively →