ZG16

Across TCGA patient cohorts, ZG16 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZG16-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Annexin-1. Each is linked with ZG16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZG16-to-partner and partner-to-ZG16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZG16-low versus ZG16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZG16→partner) and Y-score (partner→ZG16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.321	-3.000	.026	.037	3	1
UCEC	JNK2 →	+0.349	+3.000	.002	.037	2	1
UCEC	Annexin-1 →	+0.864	+3.000	.004	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

EGFR_pY1068 by ZG16 expression — UCEC

Explore this box plot interactively →