ZG16

Across TCGA pan-cancer cohorts, ZG16 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZG16 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ZG16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZG16 expression acts as an unfavorable survival marker, although some lineages such as CESC and READ show a favorable association.

MESO, HNSC, and DLBC are the cancer types where ZG16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	III,IV	0.366	0.687	<.001	85	view →
HNSC	OS	Tertile	IV	0.236	0.626	<.001	41	view →
DLBC	DFS	Tertile	III,IV	0.124	0.854	.007	35	view →
BRCA	OS	Median	II,III,IV	0.439	0.615	.001	34	view →
ESCA	OS	Tertile	All	0.489	1.000	.008	33	view →
STAD	DFS	Quartile	All	0.253	0.556	.012	30	view →
LUSC	OS	Median	II,III,IV	0.544	0.698	.006	23	view →
LGG	DFS	Tertile	All	0.742	0.868	.003	18	view →
UVM	OS	Tertile	All	0.248	0.769	.007	18	view →
CESC	OS	Median	II,III,IV	0.642	0.417	.024	16	view →
PAAD	DFS	Quartile	All	0.154	0.446	.038	15	view →
LUAD	DFS	Median	II,III,IV	0.476	0.655	.022	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZG16–MESO (OS)

Open the MESO breakdown →