ZFYVE28

Across TCGA pan-cancer cohorts, ZFYVE28 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ZFYVE28 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZFYVE28 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZFYVE28 expression acts as an unfavorable survival marker.

COAD, KIRP, and LUSC are the cancer types where ZFYVE28 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.355	0.799	<.001	16	view →
KIRP	OS	Median	All	0.199	0.903	<.001	15	view →
LUSC	OS	Median	All	0.364	0.766	<.001	11	view →
SKCM	DFS	Median	All	0.066	0.762	<.001	9	view →
BRCA	DFS	Median	III,IV	0.230	0.796	.004	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
LUAD	OS	Median	All	0.258	0.674	.036	3	view →
PRAD	DFS	Median	All	0.234	0.781	.002	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ZFYVE28–COAD (DFS)

Open the COAD breakdown →