ZFYVE28

Across TCGA pan-cancer cohorts, ZFYVE28 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZFYVE28’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZFYVE28 RNA is repressed in tumor relative to normal tissue. In most cancer types ZFYVE28 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, STAD, and HNSC are the cancer types where ZFYVE28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFYVE28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.363	<.001	10	view →
STAD	All	II,III,IV	+0.685	.002	8	view →
HNSC	Male	IV	−0.652	<.001	8	view →
THCA	All	All	−0.251	.001	8	view →
KICH	All	All	−0.805	<.001	7	view →
KIRP	All	All	−0.740	<.001	7	view →
BLCA	All	All	−0.590	.003	6	view →
BRCA	All	II,III,IV	−0.309	<.001	6	view →
READ	All	All	−1.050	<.001	5	view →
LUSC	All	All	−0.507	<.001	5	view →
PAAD	Male	All	+0.839	.036	2	view →
UCEC	All	All	−0.552	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZFYVE28–COAD

Open the COAD breakdown →