ZFYVE28

Across TCGA patient cohorts, ZFYVE28 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE28-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and IRS1. Each is linked with ZFYVE28 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFYVE28-to-partner and partner-to-ZFYVE28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZFYVE28-low versus ZFYVE28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE28→partner) and Y-score (partner→ZFYVE28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.295	+3.584	.002	.002	3	4
UCEC	Cyclin-B1 →	+0.627	+1.847	.002	.008	3	3
SKCM	IRS1 →	+0.201	+2.000	.003	.031	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.341	+1.502	.029	.030	3	2
UCEC	ACC1 →	+0.298	+2.335	.025	.018	3	2
UCEC	MEK1 →	+0.423	+1.847	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

4E-BP1 by ZFYVE28 expression — UCEC

Explore this box plot interactively →