ZFYVE27

Across TCGA patient cohorts, ZFYVE27 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE27-associated genes across cancer lineages are eIF4E, GSK-3_pS9, and Ku80. Each is linked with ZFYVE27 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFYVE27-to-partner and partner-to-ZFYVE27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZFYVE27-low versus ZFYVE27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE27→partner) and Y-score (partner→ZFYVE27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.204	+3.013	.026	.018	3	1
UCEC	GSK-3_pS9 →	-0.536	-2.321	.002	.034	3	1
UCEC	Ku80 →	+0.266	+2.128	.009	.010	3	1
UCEC	MEK1 →	+0.425	+2.584	.007	.010	3	1
UCEC	mTOR_pS2448 →	-0.158	-2.302	.015	.034	3	1
UCEC	NF-kB-p65_pS536 →	-0.481	-3.169	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by ZFYVE27 expression — UCEC

Explore this box plot interactively →