ZFYVE27

Across TCGA pan-cancer cohorts, ZFYVE27 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZFYVE27’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZFYVE27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZFYVE27 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where ZFYVE27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFYVE27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.739	<.001	11	view →
LIHC	Female	II,III,IV	+1.068	<.001	9	view →
STAD	Male	II,III,IV	+1.194	<.001	8	view →
KICH	Male	All	−0.793	<.001	7	view →
CHOL	All	All	+1.778	<.001	5	view →
KIRC	All	All	+0.248	.001	5	view →
COAD	Female	III,IV	−0.647	.018	3	view →
KIRP	All	II,III,IV	+0.360	.030	3	view →
ESCA	All	All	+0.608	.029	2	view →
READ	Male	All	−0.419	.045	2	view →
READ	Female	All	+0.540	.036	1	view →
BLCA	All	III,IV	+0.472	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZFYVE27–HNSC

Open the HNSC breakdown →