ZFYVE27

Across TCGA cell cohorts, ZFYVE27 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZFYVE27-associated genes across cancer lineages are MAGEB5, NXPH2, and OR8B12. Each is linked with ZFYVE27 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFYVE27-to-partner and partner-to-ZFYVE27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by ZFYVE27-low versus ZFYVE27-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE27→partner) and Y-score (partner→ZFYVE27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
OESOPHAGUS	NXPH2 →	+0.020	+4.017	<.001	.007	3	1
OESOPHAGUS	OR8B12 →	+0.061	+4.392	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.012	+4.887	<.001	.009	3	1
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	1
CNS	FABP12 →	+0.187	+5.566	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB5 by ZFYVE27 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →