ZFYVE1

Across TCGA cell cohorts, ZFYVE1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFYVE1-associated genes across cancer lineages are OR6T1, C20orf85, and SOX14. Each is linked with ZFYVE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFYVE1-to-partner and partner-to-ZFYVE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by ZFYVE1-low versus ZFYVE1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE1→partner) and Y-score (partner→ZFYVE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR6T1 →	+0.016	+5.196	<.001	.005	3	2
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SOX14 →	+0.005	+4.269	<.001	.002	3	1
STOMACH	TAAR8 →	+0.022	+4.285	<.001	.007	3	1
BREAST	GPR148 →	+0.062	+4.672	<.001	.002	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR6T1 by ZFYVE1 expression — OVARY

Explore this box plot interactively →