ZFY-AS1

Across TCGA pan-cancer cohorts, ZFY-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZFY-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher ZFY-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZFY-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UVM show a favorable association.

THCA, BLCA, and UVM are the cancer types where ZFY-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.972	0.997	<.001	102	view →
BLCA	DFS	Tertile	All	0.431	0.252	.003	88	view →
UVM	DFS	Median	III,IV	0.930	0.423	.003	60	view →
HNSC	OS	Median	III,IV	0.418	0.241	.001	53	view →
KIRC	OS	Quartile	II,III,IV	0.685	0.444	.001	41	view →
CESC	OS	Tertile	III,IV	0.156	0.657	.027	36	view →
STAD	DFS	Tertile	III,IV	0.193	0.613	.004	30	view →
LGG	DFS	Median	All	0.752	0.893	<.001	24	view →
ESCA	DFS	Quartile	III,IV	0.526	0.230	<.001	20	view →
BRCA	DFS	Tertile	All	0.634	0.903	.001	18	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
THYM	DFS	Tertile	II,III,IV	0.628	0.942	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZFY-AS1–THCA (OS)

Open the THCA breakdown →