ZFY-AS1

Across TCGA pan-cancer cohorts, ZFY-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZFY-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ZFY-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZFY-AS1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and HNSC are the cancer types where ZFY-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFY-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−2.567	<.001	8	view →
KICH	Male	II,III,IV	−2.293	<.001	8	view →
HNSC	Male	II,III,IV	−0.893	<.001	8	view →
THCA	Male	III,IV	−1.745	<.001	4	view →
READ	All	III,IV	−1.385	.001	4	view →
LUSC	Male	II,III,IV	−0.723	<.001	4	view →
STAD	Male	II,III,IV	−0.511	.002	4	view →
KIRC	Male	All	−0.912	.001	2	view →
PRAD	All	All	−0.555	<.001	2	view →
COAD	Male	All	−0.392	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZFY-AS1–KIRP

Open the KIRP breakdown →