ZFX

Across TCGA pan-cancer cohorts, ZFX mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZFX data layer compared with 27 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZFX mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZFX expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where ZFX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.338	.018	20	view →
HNSC	DFS	Tertile	II,III,IV	0.611	0.916	.023	4	view →
LSCC	OS	Median	II,III,IV	0.837	1.000	.044	2	view →
LUAD	DFS	Tertile	II,III,IV	0.689	1.000	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZFX–UCEC (OS)

Open the UCEC breakdown →