ZFX

Across TCGA pan-cancer cohorts, ZFX RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZFX’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZFX RNA is repressed in tumor relative to normal tissue. In most cancer types ZFX is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where ZFX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.695	<.001	8	view →
HNSC	All	All	+0.403	.001	8	view →
LIHC	All	All	+0.519	<.001	6	view →
UCEC	All	All	−0.970	<.001	4	view →
KICH	All	All	−0.652	<.001	4	view →
CHOL	All	All	+1.212	.001	3	view →
LUAD	Female	II,III,IV	−0.440	.003	3	view →
ESCA	Female	All	+0.640	.040	1	view →
KIRP	Male	All	−0.321	.024	1	view →
LUSC	Male	All	+0.276	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZFX–THCA

Open the THCA breakdown →