ZFX

Across TCGA patient cohorts, ZFX mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFX-associated genes across cancer lineages are ERK2, C-Raf, and GAPDH. Each is linked with ZFX in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFX-to-partner and partner-to-ZFX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZFX-low versus ZFX-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFX→partner) and Y-score (partner→ZFX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.230	+2.000	.014	.031	3	3
UCEC	C-Raf →	+0.126	+1.169	.002	.017	3	3
COAD	GAPDH →	+0.618	+3.008	.018	.019	3	2
UCEC	MEK1 →	+0.434	+1.954	<.001	<.001	3	2
UCEC	ATM →	-0.530	-1.736	<.001	<.001	3	2
SKCM	PCNA →	+0.178	+2.000	.039	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ERK2 by ZFX expression — SKCM

Explore this box plot interactively →