ZFX

Across TCGA cell cohorts, ZFX mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFX-associated genes across cancer lineages are LEUTX, SMIM23, and PRAMEF15. Each is linked with ZFX in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFX-to-partner and partner-to-ZFX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LEUTX grouped by ZFX-low versus ZFX-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFX→partner) and Y-score (partner→ZFX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LEUTX →	+0.245	+5.196	<.001	.005	3	1
BLOOD_Leukemia	SMIM23 →	+0.015	+4.569	<.001	.003	3	1
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
LARGE_INTESTINE	CDX4 →	+0.009	+3.632	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

LEUTX by ZFX expression — OVARY

Explore this box plot interactively →