ZFPM2

Across TCGA patient cohorts, ZFPM2 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFPM2-associated genes across cancer lineages are MSH6, Caspase-7-cleavedD198, and cIAP. Each is linked with ZFPM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFPM2-to-partner and partner-to-ZFPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by ZFPM2-low versus ZFPM2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFPM2→partner) and Y-score (partner→ZFPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MSH6 →	+0.202	+1.925	.048	.004	3	3
UCEC	Caspase-7-cleavedD198 →	+0.579	+1.447	<.001	.002	3	3
LUAD	cIAP →	+0.107	+1.770	.006	.046	3	3
UCEC	C-Raf →	+0.105	+1.273	.008	.007	3	3
UCEC	PDCD4 →	-0.545	-2.321	<.001	<.001	3	3
UCEC	ASNS →	+0.473	+2.070	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

MSH6 by ZFPM2 expression — LUAD

Explore this box plot interactively →