ZFPM2

Across TCGA pan-cancer cohorts, ZFPM2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZFPM2 data layer compared with 14 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZFPM2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZFPM2 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

UVM, LUSC, and KIRP are the cancer types where ZFPM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.417	0.752	<.001	93	view →
LUSC	DFS	Tertile	II,III,IV	0.305	0.569	.001	44	view →
KIRP	DFS	Median	All	0.788	0.942	<.001	42	view →
THCA	OS	Tertile	All	0.920	1.000	.003	41	view →
UCS	DFS	Quartile	II,III,IV	0.602	0.105	.007	22	view →
STAD	OS	Tertile	All	0.501	0.658	.004	22	view →
UCEC	DFS	Quartile	All	0.802	0.911	.002	20	view →
SKCM	OS	Median	II,III,IV	0.899	0.770	.012	19	view →
CHOL	DFS	Median	All	0.609	0.242	.018	15	view →
CESC	DFS	Tertile	All	0.382	0.726	.004	14	view →
LAML	DFS	Quartile	All	0.219	0.684	.002	14	view →
LUAD	OS	Median	II,III,IV	0.544	0.339	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZFPM2–UVM (DFS)

Open the UVM breakdown →