ZFP42

Across TCGA patient cohorts, ZFP42 mutation is significantly associated with the RNA expression of many other genes, with 3,829 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP42-associated genes across cancer lineages are MTHFD1, EXOSC9, and EIF2S1. Each is linked with ZFP42 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFP42-to-partner and partner-to-ZFP42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD1 grouped by ZFP42-low versus ZFP42-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP42→partner) and Y-score (partner→ZFP42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MTHFD1 →	+0.571	+3.471	.001	.002	3	4
COAD	EXOSC9 →	+0.446	+3.210	.005	.009	3	4
UCEC	EIF2S1 →	+0.464	+1.732	<.001	.001	3	4
BLCA	AKR1B1P3 →	+0.143	+3.822	.008	.005	3	4
LIHC	PPIAL4E →	+0.050	+3.433	.004	.006	3	3
GBM	MIR148B →	+0.855	+3.732	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,829 associations by consensus.

MTHFD1 by ZFP42 expression — LUSC

Explore this box plot interactively →