ZFP42

Across TCGA pan-cancer cohorts, ZFP42 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ZFP42 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZFP42 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZFP42 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

HNSC, LUSC, and KIRC are the cancer types where ZFP42 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.606	0.755	<.001	96	view →
LUSC	DFS	Quartile	II,III,IV	0.578	0.777	<.001	89	view →
KIRC	DFS	Quartile	All	0.669	0.838	.006	68	view →
SCLC	DFS	Quartile	III,IV	0.807	0.258	<.001	63	view →
CESC	DFS	Tertile	II,III,IV	0.560	0.756	.008	50	view →
LIHC	OS	Tertile	All	0.469	0.733	<.001	42	view →
UCS	DFS	Quartile	III,IV	0.663	0.187	.002	38	view →
BLCA	DFS	Median	All	0.283	0.376	.011	37	view →
UCEC	OS	Quartile	III,IV	0.326	0.653	.004	26	view →
UVM	DFS	Quartile	III,IV	0.272	0.757	<.001	22	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
THCA	OS	Tertile	IV	0.538	0.939	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ZFP42–HNSC (OS)

Open the HNSC breakdown →