ZFP36

Across TCGA patient cohorts, ZFP36 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP36-associated genes across cancer lineages are UQCRFS1P2, IGKV2-40, and RBM22P1. Each is linked with ZFP36 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP36-to-partner and partner-to-ZFP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRFS1P2 grouped by ZFP36-low versus ZFP36-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP36→partner) and Y-score (partner→ZFP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	UQCRFS1P2 →	+0.058	+5.250	<.001	.006	3	2
UCEC	IGKV2-40 →	+0.252	+2.631	.002	.007	3	2
CESC	RBM22P1 →	+0.038	+6.569	<.001	.001	3	2
BLCA	USP9YP2 →	+0.039	+7.640	<.001	.009	3	2
SKCM	MTATP6P20 →	+0.067	+4.513	.002	.009	3	2
HNSC	RPS10P21 →	+0.136	+4.780	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

UQCRFS1P2 by ZFP36 expression — THCA

Explore this box plot interactively →