ZFP36

Across TCGA pan-cancer cohorts, ZFP36 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ZFP36 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ZFP36 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZFP36 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

OV, ACC, and LGG are the cancer types where ZFP36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.487	0.593	.001	58	view →
ACC	DFS	Quartile	All	0.214	0.708	.001	53	view →
LGG	DFS	Median	All	0.327	0.475	<.001	48	view →
STAD	DFS	Quartile	All	0.483	0.662	.010	40	view →
UVM	DFS	Tertile	III,IV	0.283	0.689	.007	26	view →
DLBC	DFS	Median	All	0.618	0.919	.008	25	view →
UCS	DFS	Tertile	IV	0.821	0.239	.024	24	view →
LUSC	DFS	Median	All	0.582	0.696	.012	22	view →
BLCA	OS	Median	All	0.344	0.509	.015	20	view →
SCLC	DFS	Quartile	III,IV	0.634	0.271	.014	19	view →
SKCM	OS	Median	II,III,IV	0.391	0.252	.008	12	view →
GBM	DFS	Quartile	All	0.179	0.305	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ZFP36–OV (DFS)

Open the OV breakdown →