ZFP36

Across TCGA patient cohorts, ZFP36 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP36-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Ku80, and N-Ras. Each is linked with ZFP36 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP36-to-partner and partner-to-ZFP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by ZFP36-low versus ZFP36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP36→partner) and Y-score (partner→ZFP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.499	+3.321	.025	.010	3	1
UCEC	Ku80 →	+0.257	+2.183	.038	.035	3	1
UCEC	N-Ras →	-0.188	-2.980	.002	.036	3	1
UCEC	p62 Lck ligand →	+0.413	+3.009	.015	.019	3	1
UCEC	PI3K-p85 →	+0.344	+3.321	.001	.010	3	1
UCEC	SETD2 →	-0.255	-3.321	.025	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GSK-3a-b_pS21_S9 by ZFP36 expression — UCEC

Explore this box plot interactively →