ZFP36

Across TCGA cell cohorts, ZFP36 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,060 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZFP36-associated GO terms across cancer lineages are Regulation of keratinocyte apoptotic process, Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay, and Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with ZFP36 in more than 18 cancer types. Because this analysis shows association rather than direction, both ZFP36-to-partner and partner-to-ZFP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of keratinocyte apoptotic process grouped by ZFP36-low versus ZFP36-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP36→partner) and Y-score (partner→ZFP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of keratinocyte apoptotic process →	+0.301	+0.897	.008	.002	2	19
URINARY_TRACT	Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay →	+0.209	+1.595	<.001	<.001	3	18
OESOPHAGUS	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.184	+2.489	<.001	<.001	3	16
STOMACH	Positive regulation of intracellular mRNA localization →	+0.266	+2.347	<.001	<.001	3	16
KIDNEY	Negative regulation of erythrocyte differentiation →	+0.186	+1.910	<.001	<.001	3	16
STOMACH	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.157	+2.128	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,060 associations by consensus.

Regulation of keratinocyte apoptotic process by ZFP36 expression — LUNG_SCLC

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