ZFP36

Across TCGA cell cohorts, ZFP36 mutation is significantly associated with the drug of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFP36-associated genes across cancer lineages are Lapatinib, CI-1040, and AZD8055. Each is linked with ZFP36 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP36-to-partner and partner-to-ZFP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lapatinib grouped by ZFP36-low versus ZFP36-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP36→partner) and Y-score (partner→ZFP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Lapatinib →	+0.238	+2.655	.042	.044	3	2
BLOOD_Leukemia	CI-1040 →	-0.521	-2.283	.028	.024	3	1
BLOOD_Leukemia	AZD8055 →	-0.532	-3.278	<.001	.003	3	1
BLOOD_Leukemia	Thapsigargin →	+0.414	+2.667	.048	.040	3	1
BLOOD_Leukemia	Ulixertinib →	-0.289	-2.807	.042	.049	3	1
BLOOD_Leukemia	WZ-1-84 →	+0.274	+3.321	.038	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Lapatinib by ZFP36 expression — BLOOD_Leukemia

Explore this box plot interactively →