ZFP3

Across TCGA patient cohorts, ZFP3 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP3-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and Src_pY527. Each is linked with ZFP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFP3-to-partner and partner-to-ZFP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZFP3-low versus ZFP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP3→partner) and Y-score (partner→ZFP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.257	+3.169	.007	.019	3	3
UCEC	mTOR_pS2448 →	-0.130	-2.117	.002	<.001	3	3
UCEC	Src_pY527 →	-0.356	-1.916	.004	.004	3	3
UCEC	ATM →	-0.447	-1.637	<.001	.001	3	3
SKCM	4E-BP1 →	+0.431	+3.169	.009	.019	3	3
COAD	FASN →	+0.427	+2.123	.005	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

eIF4E by ZFP3 expression — SKCM

Explore this box plot interactively →