ZFHX3

Across TCGA patient cohorts, ZFHX3 mutation is significantly associated with the RNA expression of many other genes, with 9,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFHX3-associated genes across cancer lineages are ATP5F1B, NDUFC1, and BBS7. Each is linked with ZFHX3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZFHX3-to-partner and partner-to-ZFHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1B grouped by ZFHX3-low versus ZFHX3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX3→partner) and Y-score (partner→ZFHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ATP5F1B →	+0.443	+1.736	<.001	.006	3	6
UCEC	NDUFC1 →	+0.325	+1.565	<.001	<.001	3	6
UCEC	BBS7 →	+0.224	+1.005	.001	.004	3	6
UCEC	SAAL1 →	+0.440	+1.185	<.001	<.001	3	5
UCEC	UBE2L3 →	+0.333	+1.486	<.001	<.001	3	5
UCEC	PNMA8B →	-0.270	-0.954	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,606 associations by consensus.

ATP5F1B by ZFHX3 expression — STAD

Explore this box plot interactively →