ZFHX2

Across TCGA patient cohorts, ZFHX2 mutation is significantly associated with the RNA expression of many other genes, with 3,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFHX2-associated genes across cancer lineages are RN7SL134P, LDHAP1, and RNU1-17P. Each is linked with ZFHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFHX2-to-partner and partner-to-ZFHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by ZFHX2-low versus ZFHX2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX2→partner) and Y-score (partner→ZFHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL134P →	+0.172	+5.477	<.001	<.001	3	2
CESC	LDHAP1 →	+0.093	+3.652	<.001	.005	3	2
CESC	RNU1-17P →	+0.206	+3.688	<.001	.004	3	2
UCEC	HBQ1 →	+0.611	+1.858	<.001	.004	3	2
UCEC	MIR6803 →	+0.095	+3.815	<.001	<.001	3	2
UCEC	TEX43 →	+0.147	+1.195	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,555 associations by consensus.

RN7SL134P by ZFHX2 expression — BRCA

Explore this box plot interactively →