ZFHX2-AS1

Across TCGA pan-cancer cohorts, ZFHX2-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZFHX2-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZFHX2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZFHX2-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

KIRC, ACC, and BRCA are the cancer types where ZFHX2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.508	0.705	<.001	114	view →
ACC	DFS	Median	All	0.323	0.807	<.001	99	view →
BRCA	OS	Tertile	II,III,IV	0.630	0.514	.002	76	view →
LGG	OS	Median	All	0.884	0.738	<.001	49	view →
MESO	OS	Tertile	All	0.488	0.267	.014	39	view →
BLCA	OS	Tertile	II,III,IV	0.745	0.632	.019	33	view →
UVM	DFS	Quartile	III,IV	0.239	0.903	.002	33	view →
READ	DFS	Quartile	All	0.545	0.876	.008	30	view →
COAD	DFS	Quartile	All	0.326	0.674	.001	29	view →
UCEC	DFS	Quartile	All	0.457	0.779	.007	28	view →
LIHC	DFS	Tertile	All	0.409	0.604	.002	20	view →
PAAD	DFS	Tertile	II,III,IV	0.558	0.348	.015	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZFHX2-AS1–KIRC (DFS)

Open the KIRC breakdown →