ZFHX2-AS1

Across TCGA pan-cancer cohorts, ZFHX2-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZFHX2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZFHX2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZFHX2-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LIHC, BLCA, and CHOL are the cancer types where ZFHX2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFHX2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.224	<.001	9	view →
BLCA	All	All	+0.292	.003	6	view →
CHOL	All	All	+0.967	<.001	5	view →
HNSC	Male	III,IV	+0.138	.005	5	view →
COAD	Male	II,III,IV	+0.268	<.001	4	view →
STAD	All	All	+0.160	.005	4	view →
KIRC	All	All	+0.078	.003	4	view →
PRAD	All	All	+0.309	<.001	2	view →
READ	Female	All	+0.240	.028	2	view →
THCA	All	All	−0.155	.012	2	view →
KIRC	Female	IV	−0.173	.046	1	view →
KICH	All	All	−0.110	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

ZFHX2-AS1–LIHC

Open the LIHC breakdown →