ZFC3H1

Across TCGA pan-cancer cohorts, ZFC3H1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ZFC3H1 data layer compared with 30 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ZFC3H1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZFC3H1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, ESCA, and UVM are the cancer types where ZFC3H1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
ESCA	OS	Median	IV	0.095	0.512	.008	39	view →
UVM	OS	Median	All	0.037	0.858	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.900	0.300	.006	24	view →
LIHC	OS	Median	All	0.079	0.774	<.001	21	view →
SARC	OS	Median	All	0.108	0.827	<.001	6	view →
GBM	OS	Median	All	0.026	0.416	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	DFS	Median	II,III,IV	0.223	0.557	.039	6	view →
BLCA	OS	Median	IV	1.000	0.322	.028	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ZFC3H1–THYM (OS)

Open the THYM breakdown →