ZFC3H1

Across TCGA pan-cancer cohorts, ZFC3H1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZFC3H1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZFC3H1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZFC3H1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and BLCA are the cancer types where ZFC3H1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFC3H1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.443	<.001	11	view →
LIHC	All	II,III,IV	+0.890	<.001	9	view →
BLCA	All	III,IV	+0.634	.001	7	view →
KIRP	All	IV	+0.927	.005	6	view →
HNSC	All	All	+0.431	.001	6	view →
CHOL	All	All	+2.233	<.001	5	view →
COAD	Male	II,III,IV	+0.788	<.001	4	view →
LUAD	All	All	+0.390	.002	4	view →
READ	All	All	+1.006	.003	3	view →
STAD	All	II,III,IV	+0.606	.014	2	view →
KICH	All	All	−0.551	.010	2	view →
UCEC	All	All	−0.448	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZFC3H1–KIRC

Open the KIRC breakdown →