ZFC3H1

Across TCGA pan-cancer cohorts, ZFC3H1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZFC3H1 data layer compared with 30 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZFC3H1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZFC3H1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where ZFC3H1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.628	0.948	.012	9	view →
GBM	DFS	Quartile	All	0.546	0.238	.015	8	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →
LSCC	DFS	Median	All	0.936	0.568	.045	2	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.937	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZFC3H1–CCRCC (OS)

Open the CCRCC breakdown →