ZFC3H1

Across TCGA patient cohorts, ZFC3H1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFC3H1-associated genes across cancer lineages are Caspase-7-cleavedD198, Dvl3, and EGFR_pY1068. Each is linked with ZFC3H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFC3H1-to-partner and partner-to-ZFC3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZFC3H1-low versus ZFC3H1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFC3H1→partner) and Y-score (partner→ZFC3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.385	+1.019	.013	.042	3	3
LUAD	Dvl3 →	+0.230	+2.186	.003	.034	3	2
UCEC	EGFR_pY1068 →	-0.207	-1.000	.001	.020	3	2
UCEC	INPP4B →	-0.176	-1.652	.038	.004	3	2
UCEC	JNK2 →	+0.180	+1.952	<.001	.002	3	2
UCEC	p62 Lck ligand →	+0.198	+1.533	.020	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by ZFC3H1 expression — UCEC

Explore this box plot interactively →