ZFC3H1

Across TCGA cell cohorts, ZFC3H1 mutation is significantly associated with the RNA expression of many other genes, with 1,159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFC3H1-associated genes across cancer lineages are TMEM170A, NIPSNAP1, and ZC2HC1B. Each is linked with ZFC3H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFC3H1-to-partner and partner-to-ZFC3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM170A grouped by ZFC3H1-low versus ZFC3H1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFC3H1→partner) and Y-score (partner→ZFC3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM170A →	+0.479	+3.169	.006	.009	3	3
BLOOD_Leukemia	NIPSNAP1 →	+0.682	+3.199	.008	.007	3	3
SOFT_TISSUE	ZC2HC1B →	+0.053	+4.295	<.001	.002	3	2
SOFT_TISSUE	KRT6C →	+0.009	+4.515	<.001	<.001	3	2
LIVER	MYMX →	+0.220	+3.584	.002	.001	3	2
BLOOD_Lymphoma	TAS2R7 →	+0.024	+4.643	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,159 associations by consensus.

TMEM170A by ZFC3H1 expression — LARGE_INTESTINE

Explore this box plot interactively →