ZFAT

Across TCGA cell cohorts, ZFAT mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFAT-associated genes across cancer lineages are ARL6, SIRPD, and C9orf72. Each is linked with ZFAT in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFAT-to-partner and partner-to-ZFAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL6 grouped by ZFAT-low versus ZFAT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAT→partner) and Y-score (partner→ZFAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARL6 →	+0.557	+3.212	.001	.006	3	2
LARGE_INTESTINE	SIRPD →	+0.013	+2.754	<.001	.009	3	2
LARGE_INTESTINE	C9orf72 →	+0.851	+3.212	.001	.006	3	2
LARGE_INTESTINE	CCDC173 →	+0.194	+3.371	.003	.002	3	2
LARGE_INTESTINE	EML6 →	+1.250	+3.212	<.001	.006	3	2
LARGE_INTESTINE	TBC1D3 →	+0.059	+2.688	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

ARL6 by ZFAT expression — LARGE_INTESTINE

Explore this box plot interactively →