ZFAND4

Across TCGA patient cohorts, ZFAND4 mutation is significantly associated with the RNA expression of many other genes, with 4,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFAND4-associated genes across cancer lineages are PPIP5K1, PPP2R5C, and RCC1. Each is linked with ZFAND4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFAND4-to-partner and partner-to-ZFAND4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIP5K1 grouped by ZFAND4-low versus ZFAND4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAND4→partner) and Y-score (partner→ZFAND4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPIP5K1 →	+0.411	+1.906	<.001	<.001	3	4
UCEC	PPP2R5C →	+0.336	+3.222	<.001	<.001	3	4
UCEC	RCC1 →	+0.499	+1.688	<.001	<.001	3	3
UCEC	IBA57 →	+0.272	+1.537	.004	.001	3	3
UCEC	ZC3H7B →	+0.450	+2.087	<.001	<.001	3	3
UCEC	KIAA0586 →	+0.298	+2.134	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,512 associations by consensus.

PPIP5K1 by ZFAND4 expression — UCEC

Explore this box plot interactively →