ZFAND2A

Across TCGA cell cohorts, ZFAND2A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZFAND2A-associated genes across cancer lineages are ADAM7, GML, and TEX28. Each is linked with ZFAND2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFAND2A-to-partner and partner-to-ZFAND2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by ZFAND2A-low versus ZFAND2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAND2A→partner) and Y-score (partner→ZFAND2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.005	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	GML →	+0.054	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TEX28 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.037	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ADAM7 by ZFAND2A expression — LARGE_INTESTINE

Explore this box plot interactively →