ZER1

Across TCGA patient cohorts, ZER1 mutation is significantly associated with the RNA expression of many other genes, with 3,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZER1-associated genes across cancer lineages are UQCR10P1, RNU6-128P, and NF1P10. Each is linked with ZER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZER1-to-partner and partner-to-ZER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCR10P1 grouped by ZER1-low versus ZER1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZER1→partner) and Y-score (partner→ZER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	UQCR10P1 →	+0.216	+4.533	<.001	.005	3	3
CESC	RNU6-128P →	+0.398	+5.306	<.001	.006	3	2
CESC	NF1P10 →	+0.137	+6.569	.001	.001	3	2
UCEC	TAF9 →	+0.578	+4.191	<.001	<.001	3	2
UCEC	MAPK1 →	+0.518	+1.788	<.001	.001	3	2
UCEC	RANBP9 →	+0.376	+2.055	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,624 associations by consensus.

UQCR10P1 by ZER1 expression — BLCA

Explore this box plot interactively →