ZEB2

Across TCGA patient cohorts, ZEB2 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZEB2-associated genes across cancer lineages are C-Raf, S6_pS235_S236, and PCNA. Each is linked with ZEB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZEB2-to-partner and partner-to-ZEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZEB2-low versus ZEB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB2→partner) and Y-score (partner→ZEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.121	+1.125	<.001	.029	3	5
BLCA	S6_pS235_S236 →	-0.480	-2.987	.005	.035	3	4
STAD	PCNA →	+0.284	+3.000	.018	.034	3	4
LUAD	Cyclin-B1 →	+0.701	+3.321	<.001	.009	3	4
COAD	Caspase-7-cleavedD198 →	+0.920	+2.008	.004	.018	3	4
STAD	FoxM1 →	+0.345	+3.700	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

C-Raf by ZEB2 expression — UCEC

Explore this box plot interactively →