ZEB2

Across TCGA cell cohorts, ZEB2 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZEB2-associated genes across cancer lineages are R3HDML, OR52E1, and SCGB1C1. Each is linked with ZEB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZEB2-to-partner and partner-to-ZEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by ZEB2-low versus ZEB2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB2→partner) and Y-score (partner→ZEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	R3HDML →	+0.096	+3.906	.003	.002	3	2
LUNG_SCLC	OR52E1 →	+0.024	+3.584	<.001	.003	3	2
CNS	SCGB1C1 →	+0.199	+5.566	<.001	<.001	3	2
BLOOD_Lymphoma	OR4D1 →	+0.028	+3.276	<.001	.003	3	2
LUNG_NSCLC_LUAD	HSF5 →	+0.007	+3.299	.001	.003	3	2
BLOOD_Leukemia	GLYAT →	+0.204	+2.900	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

R3HDML by ZEB2 expression — LUNG_SCLC

Explore this box plot interactively →