ZEB2-AS1

Across TCGA pan-cancer cohorts, ZEB2-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZEB2-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZEB2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZEB2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

KIRC, LUAD, and UVM are the cancer types where ZEB2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.355	0.638	<.001	72	view →
LUAD	OS	Tertile	All	0.767	0.606	<.001	62	view →
UVM	DFS	Quartile	All	0.334	0.836	.002	60	view →
UCS	DFS	Tertile	II,III,IV	0.631	0.136	<.001	44	view →
KIRP	DFS	Tertile	All	1.000	0.438	<.001	43	view →
HNSC	DFS	Median	III,IV	0.448	0.235	.002	37	view →
THYM	DFS	Quartile	All	0.534	0.847	.005	22	view →
READ	OS	Median	III,IV	0.717	1.000	.005	21	view →
ACC	DFS	Quartile	All	0.198	1.000	<.001	18	view →
ESCA	OS	Quartile	III,IV	0.640	0.330	.015	16	view →
CHOL	DFS	Quartile	All	0.868	0.165	.001	14	view →
LGG	OS	Tertile	All	0.544	0.353	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZEB2-AS1–KIRC (DFS)

Open the KIRC breakdown →