ZEB2-AS1

Across TCGA pan-cancer cohorts, ZEB2-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZEB2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZEB2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZEB2-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where ZEB2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZEB2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.468	<.001	11	view →
LUAD	Female	II,III,IV	−0.427	<.001	10	view →
LUSC	Male	II,III,IV	−0.706	<.001	8	view →
KICH	Female	All	−0.669	<.001	8	view →
KIRP	All	III,IV	−0.446	<.001	8	view →
BLCA	All	All	−0.144	<.001	8	view →
BRCA	All	III,IV	−0.461	<.001	6	view →
UCEC	All	II,III,IV	−0.298	<.001	6	view →
COAD	Female	II,III,IV	−0.097	.001	5	view →
READ	Female	All	−0.142	.035	1	view →
HNSC	Female	All	+0.078	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZEB2-AS1–KIRC

Open the KIRC breakdown →